Negligible Analgesic Tolerance Seen with Extended Release Oxymorphone: APost HocAnalysis of Open-Label Longitudinal Data
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چکیده
منابع مشابه
Bioequivalence of oxymorphone extended release and crush-resistant oxymorphone extended release
BACKGROUND A formulation of crush-resistant extended-release opioids may deter abuse. The purpose of this study was to evaluate the bioequivalence of oxymorphone extended-release (Oxy-ER) and a crush-resistant formulation of oxymorphone extended-release (Oxy-CRF). METHODS In three open-label, randomized studies, healthy adults at a clinical research center received two single oral doses of Ox...
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The objectives of the study were to determine the pharmacokinetics of oxymorphone (oxy) and of ammonium sulfate-loaded, liposome-encapsulated oxymorphone (LE-ASG oxy) and to evaluate the behavioral effects of both opioid preparations by using ethographic evaluation specific to rhesus monkeys. Rhesus monkeys (n = 8) were injected with 2.0 mg/kg LE-ASG oxy s.c.. Blood samples were collected at se...
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ژورنال
عنوان ژورنال: Pain Medicine
سال: 2010
ISSN: 1526-2375,1526-4637
DOI: 10.1111/j.1526-4637.2010.00898.x